PARDIFEN

Hypersensitivity to Paracetamol, diclofenac, acetylsalicylic acid, other NSAIDs, misoprostol, other prostaglandins, or any other ingredient of the product.

• Active peptic ulcer or gastrointestinal bleeding or perforation,
•  Severe hepatic failure (Child-Pugh grade C, cirrhosis or ascites).
•  Severe kidney failure (creatinine clearance < 30 mL/min).
•  Severe cardiac failure (СН III-IV).
•  Patients who respond to diclofenac, paracetamol, aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) with bronchial asthma (“aspirin asthma”),
• urticaria or acute rhinitis, nasal polyps, and other allergic symptoms.
•  Violation of hematopoiesis of unknown origin.
•  Leukopenia.
•  Moderate and severe anemia.
•  Congenital hyperbilirubinemia.
•  Glucose-6-phosphate dehydrogenase deficiency.
•  Acute porphyria.
•  Alcoholism.
•  Asthma, urticaria or acute rhinitis
•  Patients who have history of gastrointestinal bleeding or perforation, related to the use of nonsteroidal anti-inflammatory drugs.
•  Inflammatory bowel disease (Crohn’s disease or ulcerative colitis).
•  Established congestive heart failure (NYHA II-IV), ischemic heart disease, peripheral arterial disease and/or cerebrovascular disease.
•  Pregnant women and in women planning a pregnancy.
•  Treatment of peri-operative pain in the setting of coronary bypass graft (CABG) surgery.
•  Сhildren under the age of 14 years.

Pregnancy and Nursing Mother:

• The drug is contraindicated during pregnancy or breast-feeding.

Oral use only.
The dose is determined by physician individually for each patient, depending on the patient’s age, nature and course of the disease, individual tolerance and therapeutic efficacy of the drug.

Adults and children older than 14:
1 tablet 2-3 times per day after meal.
The duration of treatment is not more than 5-7 days, and does not depend on the course of disease.
The maximum daily dose for adults and children older than 14 in not more than 3 tablets.