Ceftriaxone in Speycef has bactericidal activity resulting from the inhibition of bacterial cell wall synthesis ultimately leading to cell death.
Each vial contains:
Ceftriaxone Sodium USP (Sterile) equivalent to anhydrous Ceftriaxone – 1000 mg
Bacterial infections caused by susceptible organisms:
Speycef may be administered by deep intramuscular injection, or as a slow intravenous injection, after reconstitution of the solution.
For adults and children over 12 years: the dose is 1 – 2 g 1 time / day or 0.5 – 1 g every 12 hours, maximum daily dose – 4 g. For infants (aged 2 weeks): the dose is 20 – 50 mg / kg / day.
For infants and children up to 12 years: the daily dose is 20 – 80 mg / kg. For children weighing is 50 kg or more, the dose is like for adults. The dose of 50 mg / kg of body weight should be administered as infusion IV for 30 min. The duration of treatment depends on the nature and severity of the disease. In bacterial meningitis in infants and young children, the dose is 100 mg / kg 1 time / day. The maximum daily dose – 4 g. Duration of therapy depends on the type of pathogen and can range from 4 days in meningitis caused by Neisseria meningitidis, and 10 – 14 days in meningitis caused by susceptible strains of Enterobacteriaceae. For the treatment of gonorrhea the dose is 250 mg intramuscularly, once.
Peri-operative prophylaxis: Usually one dose of 1g given by intramuscular or slow intravenous injection. In colorectal surgery, 2g should be given intramuscularly (in divided doses at different injection sites), by slow intravenous injection or by slow intravenous infusion, in coevery 12 hours, but not more than 2 g / day. In severe infections at other sites – at a dose of 25 – 37.5 mg / kg every 12 hours, but not more than 2 g / day. Otitis media the drug is administered IM – 50 mg / kg of body weight, but not more than 1 g.
In patients with impaired renal function, there is no need to reduce the dosage of ceftriaxone provided liver function is intact. Only in cases of pre-terminal renal failure (creatinine clearance <10ml per minute) should the daily dosage be limited to 2g or less. Injections should be prepared immediately before use. To prepare the solution for injection IM, 0.5 g dissolved in 2 ml and 1g of product – 3.5 ml of 1% lidocaine. It is recommended that not more than 1 g in one buttock.
To prepare the solution for IV injection, 0.5 g dissolved in 5 ml, and 1g of the preparation – 10 ml of sterile water for injection. Injection solution administered IV (slowly) for 2 – 4 minutes. To prepare the solution for IV infusion of 2 g of the drug dissolved in 40 ml of one of the following solutions containing calcium: 0.9% sodium chloride, 5 – 10% dextrose (glucose), levulose 5% solution. Preparation of 50 mg / kg and more to be administered IV drip for 30 min. njunction with a suitable agent against anaerobic bacteria.
Children with infections of skin and soft tissue preparation is administered in a daily dose 50 – 75 mg / kg of body weight one time / day or 25 – 37.5 mg / kg
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