Ampicillin and sulbactam in Speybact is a combination of the common penicillin-derived antibiotic ampicillin and sulbactam, an inhibitor of bacterial beta-lactamase.
Each vial contains: ampicillin sodium USP (Sterile) eq. to Anhydrous Ampicillin – 0.5 g, sulbactam sodium USP (Sterile) eq. to Sulbactam – 0.25 g
Bacterial infections of different localization caused by susceptible pathogens:
Speybact may be administered by either the IV or the IM routes (drip at a rate of 60-80 drops/min, jet – slowly during 3-5 min). IV administered 5-7 days, and then, if necessary further treatment, should to use IM route. Further are the total doses of ampicillin and sulbactam ( is 2:1).
Mild infection – 1.5-3 g / day in 2 administration; with moderate flow 3-6 g/day in 3-4 introduction; in severe – 12 g/day in 3-4 administration.
Uncomplicated gonorrhea – 1.5 g, once. Prevention of surgical site infections – 1.5-3 g during anesthesia, and then for 24 hours after the operation – at the same dose every 6-8 hours. Children – a daily dose rate is 150 mg/kg (of 100 mg/kg ampicillin and 50 mg/kg sulbactam); multiple – 3-4 times per day.
Newborns till 1 week of life and premature babies – every 12 hours. Duration of treatment 5-14 days (if necessary, may be extended). After normalization of temperature and the disappearance of other pathological symptoms treatment should be continued for a further 48 hours.
With chronic renal failure (creatinine clearance less than 30 mL / min) to increase the intervals between injections. The solution for parenteral administration is prepared ex tempore. To the contents of the vial were added 2 or 4 ml of water for injection 0.5% solution of procaine or 0.9% solution of NaCl. For the IM is acceptable dilution of 0.5% lidocaine. For IV single dose administration is dissolved in 0.9% NaCl solution or 5% dextrose solution in a volume of 10 to 200 ml.
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